4L6C
Crystal structure of human mitochondrial deoxyribonucleotidase in complex with the inhibitor pib-t
Summary for 4L6C
| Entry DOI | 10.2210/pdb4l6c/pdb |
| Related | 4L6A |
| Descriptor | 5'(3')-deoxyribonucleotidase, mitochondrial, MAGNESIUM ION, PHOSPHATE ION, ... (7 entities in total) |
| Functional Keywords | 5'-nucleotidase, mitochondria, protein conformation, sequence homology, had-like, hydrolase, dephosphorylation, phosphorylation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Mitochondrion: Q9NPB1 |
| Total number of polymer chains | 1 |
| Total formula weight | 24695.81 |
| Authors | Pachl, P.,Brynda, J.,Rezacova, P. (deposition date: 2013-06-12, release date: 2014-09-10, Last modification date: 2024-02-28) |
| Primary citation | Simak, O.,Pachl, P.,Fabry, M.,Budesinsky, M.,Jandusik, T.,Hnizda, A.,Sklenickova, R.,Petrova, M.,Veverka, V.,Rezacova, P.,Brynda, J.,Rosenberg, I. Conformationally constrained nucleoside phosphonic acids - potent inhibitors of human mitochondrial and cytosolic 5'(3')-nucleotidases. Org.Biomol.Chem., 12:7971-7982, 2014 Cited by PubMed: 25178098DOI: 10.1039/c4ob01332h PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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