4L5M
Complexe of ARNO Sec7 domain with the protein-protein interaction inhibitor N-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide at pH6.5
Summary for 4L5M
Entry DOI | 10.2210/pdb4l5m/pdb |
Related | 4JHX 4JMI 4JMO 4JWL |
Descriptor | Cytohesin-2, PHOSPHATE ION, N-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide, ... (4 entities in total) |
Functional Keywords | sec-7domain, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane: Q99418 |
Total number of polymer chains | 1 |
Total formula weight | 25290.72 |
Authors | Hoh, F.,Rouhana, J. (deposition date: 2013-06-11, release date: 2013-10-30, Last modification date: 2024-05-29) |
Primary citation | Rouhana, J.,Hoh, F.,Estaran, S.,Henriquet, C.,Boublik, Y.,Kerkour, A.,Trouillard, R.,Martinez, J.,Pugniere, M.,Padilla, A.,Chavanieu, A. Fragment-based identification of a locus in the Sec7 domain of Arno for the design of protein-protein interaction inhibitors. J.Med.Chem., 56:8497-8511, 2013 Cited by PubMed: 24112024DOI: 10.1021/jm4009357 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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