4L5L

Crystal structure of 26 kDa GST of Clonorchis sinensis in P212121 symmetry

4L5L の概要

• エントリーDOI: 10.2210/pdb4l5l/pdb
• 関連するPDBエントリー: 3ISO 4L5O
• 分子名称: Putative glutathione transferase, GLUTATHIONE, ZINC ION, ... (5 entities in total)
• 機能のキーワード: transferase, gsh binding
• 由来する生物種: Clonorchis sinensis (oriental liver fluke)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 51267.12

構造登録者

Chung, Y.J.,Han, Y.H. (登録日: 2013-06-11, 公開日: 2013-09-04, 最終更新日: 2024-03-20)

主引用文献

Han, Y.H.,Hong, S.J.,Cheong, H.K.,Chung, Y.J.
Crystal structures of 26kDa Clonorchis sinensis glutathione S-transferase reveal zinc binding and putative metal binding.
Biochem.Biophys.Res.Commun., 438:457-461, 2013

PubMed Abstract: The crystal structures of CsGST in two different space groups revealed that Asp26 and His79 coordinate a zinc ion. In one space group, His46 of an adjacent molecule participates in the coordination within 2.0Å. In the other space group, Asp26, His79 and a water molecule coordinate a zinc ion. The CsGST-D26H structure showed that four histidine residues - His26 and His79 from one molecule and the same residues from a symmetry-related neighboring molecule - coordinate a zinc ion. The coordinated zinc ions are located between two molecules and mediate molecular contacts within the crystal.

PubMed: 23916611
DOI: 10.1016/j.bbrc.2013.07.102

実験手法

X-RAY DIFFRACTION (2.2 Å)