4L04

Crystal Structure Analysis of human IDH1 mutants in complex with NADP+ and Ca2+/alpha-Ketoglutarate

Summary for 4L04

• Entry DOI: 10.2210/pdb4l04/pdb
• Related: 4KZO 4L03 4L06
• Descriptor: Isocitrate dehydrogenase [NADP] cytoplasmic, 2-OXOGLUTARIC ACID, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: cytosolic, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : O75874
• Total number of polymer chains: 6
• Total formula weight: 294848.17

Authors

Concha, N.O.,Smallwood, A.M. (deposition date: 2013-05-30, release date: 2013-07-31, Last modification date: 2024-02-28)

• Primary citation: Rendina, A.R.,Pietrak, B.,Smallwood, A.,Zhao, H.,Qi, H.,Quinn, C.,Adams, N.D.,Concha, N.,Duraiswami, C.,Thrall, S.H.,Sweitzer, S.,Schwartz, B.; Mutant IDH1 Enhances the Production of 2-Hydroxyglutarate Due to Its Kinetic Mechanism.; Biochemistry, 52:4563-4577, 2013; PubMed: 23731180; DOI: 10.1021/bi400514k

Experimental method

X-RAY DIFFRACTION (2.87 Å)