4KY0

Crystal structure of a substrate-free glutamate transporter homologue from Thermococcus kodakarensis

4KY0 の概要

• エントリーDOI: 10.2210/pdb4ky0/pdb
• 分子名称: Proton/glutamate symporter, SDF family, TETRAETHYLENE GLYCOL (2 entities in total)
• 機能のキーワード: amino acid transporter, aspartate transport, glutamate transport homologue, transport protein, membrane protein
• 由来する生物種: Thermococcus kodakarensis
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 137931.95

構造登録者

Guskov, A.,Jensen, S.,Rempel, S.,Hanelt, I.,Slotboom, D.J. (登録日: 2013-05-28, 公開日: 2013-09-11, 最終更新日: 2023-09-20)

主引用文献

Jensen, S.,Guskov, A.,Rempel, S.,Hanelt, I.,Slotboom, D.J.
Crystal structure of a substrate-free aspartate transporter.
Nat.Struct.Mol.Biol., 20:1224-1226, 2013

PubMed Abstract: Archaeal glutamate transporter homologs catalyze the coupled uptake of aspartate and three sodium ions. After the delivery of the substrate and sodium ions to the cytoplasm, the empty binding site must reorient to the outward-facing conformation to reset the transporter. Here, we report a crystal structure of the substrate-free transporter GltTk from Thermococcus kodakarensis, which provides insight into the mechanism of this essential step in the translocation cycle.

PubMed: 24013209
DOI: 10.1038/nsmb.2663

実験手法

X-RAY DIFFRACTION (3 Å)