4KV3

Ubiquitin-like domain of the Mycobacterium tuberculosis type VII secretion system protein EccD1 as maltose-binding protein fusion

4KV3 の概要

• エントリーDOI: 10.2210/pdb4kv3/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900001
• 分子名称: Chimera fusion protein of ESX-1 secretion system protein eccD1 and Maltose-binding periplasmic protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose (3 entities in total)
• 機能のキーワード: esx-1, esx, snm4, ubiquitin, yukd, pf08817, membrane protein, protein secretion, mbp fusion, protein transport
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100745.79

構造登録者

Korotkov, K.V.,Evans, T.J. (登録日: 2013-05-22, 公開日: 2014-04-09, 最終更新日: 2023-09-20)

主引用文献

Wagner, J.M.,Chan, S.,Evans, T.J.,Kahng, S.,Kim, J.,Arbing, M.A.,Eisenberg, D.,Korotkov, K.V.
Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system.
Bmc Struct.Biol., 16:5-5, 2016

PubMed Abstract: The ESX-1 type VII secretion system is an important determinant of virulence in pathogenic mycobacteria, including Mycobacterium tuberculosis. This complicated molecular machine secretes folded proteins through the mycobacterial cell envelope to subvert the host immune response. Despite its important role in disease very little is known about the molecular architecture of the ESX-1 secretion system.

PubMed: 26922638
DOI: 10.1186/s12900-016-0056-6

実験手法

X-RAY DIFFRACTION (2.2 Å)