4KV1
Crystal Structure of Brd4 Bromodomain 1 in Complex with Acetylated Rel Peptide
Summary for 4KV1
Entry DOI | 10.2210/pdb4kv1/pdb |
Related | 4KV4 |
Descriptor | Bromodomain-containing protein 4, Rel peptide (3 entities in total) |
Functional Keywords | rel, p65, bromodomain, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: O60885 Q04206 |
Total number of polymer chains | 4 |
Total formula weight | 32135.14 |
Authors | Zhang, H.,Nair, S.K. (deposition date: 2013-05-22, release date: 2013-06-26, Last modification date: 2014-05-14) |
Primary citation | Zou, Z.,Huang, B.,Wu, X.,Zhang, H.,Qi, J.,Bradner, J.,Nair, S.,Chen, L.F. Brd4 maintains constitutively active NF-kappa B in cancer cells by binding to acetylated RelA. Oncogene, 33:2395-2404, 2014 Cited by PubMed: 23686307DOI: 10.1038/onc.2013.179 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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