4KSP
Crystal Structure of Human B-raf bound to a DFG-out Inhibitor TAK-632
Summary for 4KSP
Entry DOI | 10.2210/pdb4ksp/pdb |
Related | 3Q96 4DBN 4KSQ |
Descriptor | Serine/threonine-protein kinase B-raf, N-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]acetyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamide (3 entities in total) |
Functional Keywords | human serine/theronine protein kinase, kinase drug complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P15056 |
Total number of polymer chains | 2 |
Total formula weight | 65753.79 |
Authors | Yano, J.K.,Masanori, O. (deposition date: 2013-05-17, release date: 2013-07-24, Last modification date: 2023-09-20) |
Primary citation | Okaniwa, M.,Hirose, M.,Arita, T.,Yabuki, M.,Nakamura, A.,Takagi, T.,Kawamoto, T.,Uchiyama, N.,Sumita, A.,Tsutsumi, S.,Tottori, T.,Inui, Y.,Sang, B.C.,Yano, J.,Aertgeerts, K.,Yoshida, S.,Ishikawa, T. Discovery of a Selective Kinase Inhibitor (TAK-632) Targeting Pan-RAF Inhibition: Design, Synthesis, and Biological Evaluation of C-7-Substituted 1,3-Benzothiazole Derivatives. J.Med.Chem., 56:6478-6494, 2013 Cited by PubMed: 23906342DOI: 10.1021/jm400778d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.93 Å) |
Structure validation
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