4KCX
BRDT in complex with Dinaciclib
Summary for 4KCX
| Entry DOI | 10.2210/pdb4kcx/pdb |
| Descriptor | Bromodomain testis-specific protein, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, CHLORIDE ION, ... (4 entities in total) |
| Functional Keywords | brdt, bromodomain containing protein testis specific, cell cycle-inhibitor complex, cell cycle/inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus: Q58F21 |
| Total number of polymer chains | 2 |
| Total formula weight | 28726.75 |
| Authors | Martin, M.P.,Schonbrunn, E. (deposition date: 2013-04-24, release date: 2013-09-18, Last modification date: 2023-09-20) |
| Primary citation | Martin, M.P.,Olesen, S.H.,Georg, G.I.,Schonbrunn, E. Cyclin-dependent kinase inhibitor dinaciclib interacts with the acetyl-lysine recognition site of bromodomains. Acs Chem.Biol., 8:2360-2365, 2013 Cited by PubMed: 24007471DOI: 10.1021/cb4003283 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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