4KCQ
Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-(4-(2-(ethyl(3-(thiophene-2-carboximidamido)benzyl)amino)ethyl)phenyl)thiophene-2-carboximidamide
Summary for 4KCQ
Entry DOI | 10.2210/pdb4kcq/pdb |
Related | 4KCH 4KCI 4KCJ 4KCK 4KCL 4KCM 4KCN 4KCO 4KCP 4KCR 4KCS |
Descriptor | Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (8 entities in total) |
Functional Keywords | nitric oxide synthase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Bos taurus (bovine) |
Cellular location | Cell membrane : P29473 |
Total number of polymer chains | 2 |
Total formula weight | 102630.63 |
Authors | Li, H.,Poulos, T.L. (deposition date: 2013-04-24, release date: 2014-02-12, Last modification date: 2023-09-20) |
Primary citation | Huang, H.,Li, H.,Yang, S.,Chreifi, G.,Martasek, P.,Roman, L.J.,Meyskens, F.L.,Poulos, T.L.,Silverman, R.B. Potent and Selective Double-Headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma. J.Med.Chem., 57:686-700, 2014 Cited by PubMed: 24447275DOI: 10.1021/jm401252e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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