4K65

Structure of an airborne transmissible avian influenza H5 hemagglutinin mutant from the influenza virus A/Indonesia/5/2005

4K65 の概要

• エントリーDOI: 10.2210/pdb4k65/pdb
• 関連するPDBエントリー: 4K62 4K63 4K64 4K66 4K67
• 分子名称: Hemagglutinin, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: virus attachment, membrane fusion, viral protein
• 由来する生物種: Influenza A virus; 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 220901.58

構造登録者

Zhang, W.,Shi, Y.,Lu, X.,Shu, Y.,Qi, J.,Gao, G.F. (登録日: 2013-04-15, 公開日: 2013-05-22, 最終更新日: 2024-10-30)

主引用文献

Zhang, W.,Shi, Y.,Lu, X.,Shu, Y.,Qi, J.,Gao, G.F.
An airborne transmissible avian influenza H5 hemagglutinin seen at the atomic level.
Science, 340:1463-1467, 2013

PubMed Abstract: Recent studies have identified several mutations in the hemagglutinin (HA) protein that allow the highly pathogenic avian H5N1 influenza A virus to transmit between mammals by airborne route. Here, we determined the complex structures of wild-type and mutant HAs derived from an Indonesia H5N1 virus bound to either avian or human receptor sialic acid analogs. A cis/trans conformational change in the glycosidic linkage of the receptor analog was observed, which explains how the H5N1 virus alters its receptor-binding preference. Furthermore, the mutant HA possessed low affinities for both avian and human receptors. Our findings provide a structural and biophysical basis for the H5N1 adaptation to acquire human, but maintain avian, receptor-binding properties.

PubMed: 23641058
DOI: 10.1126/science.1236787

実験手法

X-RAY DIFFRACTION (2.9 Å)