4JXF

Crystal Structure of PLK4 Kinase with an inhibitor: 400631 ((1R,2S)-2-{3-[(E)-2-{4-[(DIMETHYLAMINO)METHYL]PHENYL}ETHENYL]-2H-INDAZOL-6-YL}-5'-METHOXYSPIRO[CYCLOPROPANE-1,3'-INDOL]-2'(1'H)-ONE)

4JXF の概要

• エントリーDOI: 10.2210/pdb4jxf/pdb
• 分子名称: Serine/threonine-protein kinase PLK4, (1R,2S)-2-{3-[(E)-2-{4-[(dimethylamino)methyl]phenyl}ethenyl]-2H-indazol-6-yl}-5'-methoxyspiro[cyclopropane-1,3'-indol]-2'(1'H)-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: serine/threonine kinase, polo-like kinase 4, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole: O00444
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31105.07

構造登録者

Qiu, W.,Plotnikova, O.,Feher, M.,Awrey, D.E.,Chirgadze, N.Y. (登録日: 2013-03-28, 公開日: 2014-04-02, 最終更新日: 2023-09-20)

• 主引用文献: Qiu, W.,Plotnikova, O.,Feher, M.,Awrey, D.E.,Chirgadze, N.Y.; Crystal Structure of PLK4 Kinase with an inhibitor: 400631; To be Published,

実験手法

X-RAY DIFFRACTION (2.4 Å)