4JWL

Complexe of ARNO Sec7 domain with the protein-protein interaction inhibitor N-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide at pH7.5

4JWL の概要

• エントリーDOI: 10.2210/pdb4jwl/pdb
• 関連するPDBエントリー: 4JMI 4JMO 4JXH 4L5M
• 分子名称: Cytohesin-2, N-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide (3 entities in total)
• 機能のキーワード: signaling protein, arf1, signaling protein-inhibitor complex, signaling protein/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Peripheral membrane protein: Q99418
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25195.75

構造登録者

Hoh, F.,Rouhana, J. (登録日: 2013-03-27, 公開日: 2013-10-23, 最終更新日: 2023-11-08)

• 主引用文献: Rouhana, J.,Hoh, F.,Estaran, S.,Henriquet, C.,Boublik, Y.,Kerkour, A.,Trouillard, R.,Martinez, J.,Pugniere, M.,Padilla, A.,Chavanieu, A.; Fragment-based identification of a locus in the Sec7 domain of Arno for the design of protein-protein interaction inhibitors; J.Med.Chem., 56:8497-8511, 2013; PubMed: 24112024; DOI: 10.1021/jm4009357

実験手法

X-RAY DIFFRACTION (1.95 Å)