4JVM

Crystal structure of human estrogen sulfotransferase (SULT1E1) in complex with inactive cofactor PAP and brominated flame retardant TBBPA (tetrabromobisphenol A)

4JVM の概要

• エントリーDOI: 10.2210/pdb4jvm/pdb
• 関連するPDBエントリー: 1G3M 4JVL 4JVN
• 分子名称: Estrogen sulfotransferase, 4,4'-propane-2,2-diylbis(2,6-dibromophenol), ADENOSINE-3'-5'-DIPHOSPHATE, ... (6 entities in total)
• 機能のキーワード: cytosolic sulfotransferase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P49888
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72672.10

構造登録者

Gosavi, R.A.,Knudsen, G.A.,Birnbaum, L.S.,Pedersen, L.C. (登録日: 2013-03-25, 公開日: 2013-09-04, 最終更新日: 2023-09-20)

主引用文献

Gosavi, R.A.,Knudsen, G.A.,Birnbaum, L.S.,Pedersen, L.C.
Mimicking of Estradiol Binding by Flame Retardants and Their Metabolites: A Crystallographic Analysis.
Environ.Health Perspect., 121:1194-1199, 2013

PubMed Abstract: Brominated flame retardants (BFRs), used in many types of consumer goods, are being studied because of concerns about possible health effects related to endocrine disruption, immunotoxicity, reproductive toxicity, and neurotoxicity. Tetrabromobisphenol A (TBBPA), the most widely used BFR, and human metabolites of certain congeners of polybrominated diphenyl ether (e.g., 3-OH-BDE-47) have been suggested to inhibit estrogen sulfotransferase, potentially affecting estrogen metabolism.

PubMed: 23959441
DOI: 10.1289/ehp.1306902

実験手法

X-RAY DIFFRACTION (1.994 Å)