4JT9

Crystal Structure of human SIRT3 with ELT inhibitor 3 [14-(4-{2-[(methylsulfonyl)amino]ethyl}piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide]

4JT9 の概要

• エントリーDOI: 10.2210/pdb4jt9/pdb
• 関連するPDBエントリー: 4JSR 4JT8
• 分子名称: NAD-dependent protein deacetylase sirtuin-3, mitochondrial, ZINC ION, 4-(4-{2-[(methylsulfonyl)amino]ethyl}piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide, ... (6 entities in total)
• 機能のキーワード: deacetylase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion matrix: Q9NTG7
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32268.42

構造登録者

Dai, H. (登録日: 2013-03-22, 公開日: 2013-04-24, 最終更新日: 2024-02-28)

• 主引用文献: Disch, J.S.,Evindar, G.,Chiu, C.H.,Blum, C.A.,Dai, H.,Jin, L.,Schuman, E.,Lind, K.E.,Belyanskaya, S.L.,Deng, J.,Coppo, F.,Aquilani, L.,Graybill, T.L.,Cuozzo, J.W.,Lavu, S.,Mao, C.,Vlasuk, G.P.,Perni, R.B.; Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3.; J.Med.Chem., 56:3666-3679, 2013; PubMed: 23570514; DOI: 10.1021/jm400204k

実験手法

X-RAY DIFFRACTION (2.24 Å)