4JSD

The X-ray crystal structure of a thermophilic cellobiose binding protein bound with laminaribiose

4JSD の概要

• エントリーDOI: 10.2210/pdb4jsd/pdb
• 関連するPDBエントリー: 2O7I 3I5O 4JSO
• 関連するBIRD辞書のPRD_ID: PRD_900024
• 分子名称: Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein, beta-D-glucopyranose-(1-3)-beta-D-glucopyranose, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: periplasmic binding protein, thermophilic protein, cellulose, sugar binding protein, cellobiose binding protein
• 由来する生物種: Thermotoga maritima
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 67792.46

構造登録者

Munshi, P.,Cuneo, M.J. (登録日: 2013-03-22, 公開日: 2013-10-09, 最終更新日: 2023-09-20)

主引用文献

Munshi, P.,Stanley, C.B.,Ghimire-Rijal, S.,Lu, X.,Myles, D.A.,Cuneo, M.J.
Molecular details of ligand selectivity determinants in a promiscuous beta-glucan periplasmic binding protein.
Bmc Struct.Biol., 13:18-18, 2013

PubMed Abstract: Members of the periplasmic binding protein (PBP) superfamily utilize a highly conserved inter-domain ligand binding site that adapts to specifically bind a chemically diverse range of ligands. This paradigm of PBP ligand binding specificity was recently altered when the structure of the Thermotoga maritima cellobiose-binding protein (tmCBP) was solved. The tmCBP binding site is bipartite, comprising a canonical solvent-excluded region (subsite one), adjacent to a solvent-filled cavity (subsite two) where specific and semi-specific ligand recognition occur, respectively.

PubMed: 24090243
DOI: 10.1186/1472-6807-13-18

実験手法

X-RAY DIFFRACTION (2.05 Å)