4JPG
2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as Novel PKM2 Activators
Summary for 4JPG
Entry DOI | 10.2210/pdb4jpg/pdb |
Descriptor | Pyruvate kinase isozymes M1/M2, 1,6-di-O-phosphono-beta-D-fructofuranose, 2-(1H-benzimidazol-1-ylmethyl)-4H-pyrido[1,2-a]pyrimidin-4-one, ... (4 entities in total) |
Functional Keywords | pyruvate kinase, transferase-transferase activator complex, transferase/transferase activator |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 245725.36 |
Authors | Greasley, S.E.,Hickey, M.,Phonephaly, H.,Cronin, C. (deposition date: 2013-03-19, release date: 2013-05-22, Last modification date: 2024-02-28) |
Primary citation | Guo, C.,Linton, A.,Jalaie, M.,Kephart, S.,Ornelas, M.,Pairish, M.,Greasley, S.,Richardson, P.,Maegley, K.,Hickey, M.,Li, J.,Wu, X.,Ji, X.,Xie, Z. Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators. Bioorg.Med.Chem.Lett., 23:3358-3363, 2013 Cited by PubMed: 23622982DOI: 10.1016/j.bmcl.2013.03.090 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.33 Å) |
Structure validation
Download full validation report