4JNK

Lactate Dehydrogenase A in complex with inhibitor compound 22

Summary for 4JNK

Entry DOI	10.2210/pdb4jnk/pdb
Descriptor	L-lactate dehydrogenase A chain, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (7 entities in total)
Functional Keywords	alpha-beta, pyruvate reductase and lactate dehydrogenase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00338
Total number of polymer chains	4
Total formula weight	151742.04
Authors	Eigenbrot, C.,Ultsch, M. (deposition date: 2013-03-15, release date: 2013-05-22, Last modification date: 2023-11-15)
Primary citation	Dragovich, P.S.,Fauber, B.P.,Corson, L.B.,Ding, C.Z.,Eigenbrot, C.,Ge, H.,Giannetti, A.M.,Hunsaker, T.,Labadie, S.,Liu, Y.,Malek, S.,Pan, B.,Peterson, D.,Pitts, K.,Purkey, H.E.,Sideris, S.,Ultsch, M.,Vanderporten, E.,Wei, B.,Xu, Q.,Yen, I.,Yue, Q.,Zhang, H.,Zhang, X. Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase. Bioorg.Med.Chem.Lett., 23:3186-3194, 2013 Cited by PubMed: 23628333 DOI: 10.1016/j.bmcl.2013.04.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.896 Å)

Structure validation