4JNK

Lactate Dehydrogenase A in complex with inhibitor compound 22

4JNK の概要

• エントリーDOI: 10.2210/pdb4jnk/pdb
• 分子名称: L-lactate dehydrogenase A chain, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (7 entities in total)
• 機能のキーワード: alpha-beta, pyruvate reductase and lactate dehydrogenase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P00338
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 151742.04

構造登録者

Eigenbrot, C.,Ultsch, M. (登録日: 2013-03-15, 公開日: 2013-05-22, 最終更新日: 2023-11-15)

• 主引用文献: Dragovich, P.S.,Fauber, B.P.,Corson, L.B.,Ding, C.Z.,Eigenbrot, C.,Ge, H.,Giannetti, A.M.,Hunsaker, T.,Labadie, S.,Liu, Y.,Malek, S.,Pan, B.,Peterson, D.,Pitts, K.,Purkey, H.E.,Sideris, S.,Ultsch, M.,Vanderporten, E.,Wei, B.,Xu, Q.,Yen, I.,Yue, Q.,Zhang, H.,Zhang, X.; Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase.; Bioorg.Med.Chem.Lett., 23:3186-3194, 2013; PubMed: 23628333; DOI: 10.1016/j.bmcl.2013.04.001

実験手法

X-RAY DIFFRACTION (1.896 Å)