4JMO
Complexe of ARNO Sec7 domain with the protein-protein interaction inhibitor N-(4-hydroxy-2,6-dimethylphenyl)-4-methoxybenzenesulfonamide
Summary for 4JMO
Entry DOI | 10.2210/pdb4jmo/pdb |
Related | 4JMI 4JWL 4JXH 4L5M |
Descriptor | Cytohesin-2, N-(4-hydroxy-2,6-dimethylphenyl)-4-methoxybenzenesulfonamide (3 entities in total) |
Functional Keywords | nucleotide exchange factor, arf1, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Peripheral membrane protein: Q99418 |
Total number of polymer chains | 1 |
Total formula weight | 23336.68 |
Authors | Hoh, F.,Rouhana, J. (deposition date: 2013-03-14, release date: 2013-10-23, Last modification date: 2023-11-08) |
Primary citation | Rouhana, J.,Hoh, F.,Estaran, S.,Henriquet, C.,Boublik, Y.,Kerkour, A.,Trouillard, R.,Martinez, J.,Pugniere, M.,Padilla, A.,Chavanieu, A. Fragment-based identification of a locus in the Sec7 domain of Arno for the design of protein-protein interaction inhibitors J.Med.Chem., 56:8497-8511, 2013 Cited by PubMed: 24112024DOI: 10.1021/jm4009357 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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