4JLS

Crystal Structure of E. coli XGPRT in complex with (3R,4S)-4-(Guanin-9-yl)-3-hydroxypyrrolidin-1-N-ylacetylphosphonic acid

4JLS の概要

• エントリーDOI: 10.2210/pdb4jls/pdb
• 関連するPDBエントリー: 4JIT
• 分子名称: Xanthine phosphoribosyltransferase, {2-[(3S,4R)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-hydroxypyrrolidin-1-yl]-2-oxoethyl}phosphonic acid (3 entities in total)
• 機能のキーワード: xanthine-guanine phosphoribosyltransferase, purine salvage, nucleoside phosphonate, antibacterial, transferase
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cell membrane ; Peripheral membrane protein : H0Q6L9
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 138798.52

構造登録者

Keough, D.T.,Hockova, D.,Rejman, D.,Spacek, P.,Vrbkova, S.,Krecmerova, M.,Eng, W.S.,Jans, H.,West, N.P.,Naesens, L.M.J.,de Jersey, J.,Guddat, L.W. (登録日: 2013-03-12, 公開日: 2014-12-24, 最終更新日: 2024-02-28)

• 主引用文献: Keough, D.T.,Hockova, D.,Rejman, D.,Spacek, P.,Vrbkova, S.,Krecmerova, M.,Eng, W.S.,Jans, H.,West, N.P.,Naesens, L.M.,de Jersey, J.,Guddat, L.W.; Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents.; J.Med.Chem., 56:6967-6984, 2013; PubMed: 23927482; DOI: 10.1021/jm400779n

実験手法

X-RAY DIFFRACTION (2.2 Å)