4JL7

Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1

Summary for 4JL7

Entry DOI	10.2210/pdb4jl7/pdb
Descriptor	Na(+)/H(+) exchange regulatory cofactor NHE-RF1, CHLORIDE ION (3 entities in total)
Functional Keywords	cxcr2, nherf1, neutrophil, inflammatory diseases, signaling protein
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): O14745
Total number of polymer chains	1
Total formula weight	9966.68
Authors	Lu, G.,Wu, Y.,Jiang, Y.,Brunzelle, J.,Sirinupong, N.,Li, C.,Yang, Z. (deposition date: 2013-03-12, release date: 2013-10-23, Last modification date: 2024-02-28)
Primary citation	Lu, G.,Wu, Y.,Jiang, Y.,Wang, S.,Hou, Y.,Guan, X.,Brunzelle, J.,Sirinupong, N.,Sheng, S.,Li, C.,Yang, Z. Structural Insights into Neutrophilic Migration Revealed by the Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1. Plos One, 8:e76219-e76219, 2013 Cited by PubMed: 24098448 DOI: 10.1371/journal.pone.0076219 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.16 Å)

Structure validation