4JKV

Structure of the human smoothened 7TM receptor in complex with an antitumor agent

Summary for 4JKV

Entry DOI	10.2210/pdb4jkv/pdb
Descriptor	Soluble cytochrome b562, Smoothened homolog, 4-fluoro-N-methyl-N-{1-[4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl]piperidin-4-yl}-2-(trifluoromethyl)benzamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (8 entities in total)
Functional Keywords	human smoothened receptor, antitumor agent, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, membrane
Biological source	Escherichia coli (human) More
Cellular location	Membrane ; Multi-pass membrane protein : Q99835
Total number of polymer chains	2
Total formula weight	110453.73
Authors	Wang, C.,Wu, H.,Katritch, V.,Han, G.W.,Huang, X.,Liu, W.,Siu, F.Y.,Roth, B.L.,Cherezov, V.,Stevens, R.C.,GPCR Network (GPCR) (deposition date: 2013-03-11, release date: 2013-04-24, Last modification date: 2024-04-03)
Primary citation	Wang, C.,Wu, H.,Katritch, V.,Han, G.W.,Huang, X.P.,Liu, W.,Siu, F.Y.,Roth, B.L.,Cherezov, V.,Stevens, R.C. Structure of the human smoothened receptor bound to an antitumour agent. Nature, 497:338-343, 2013 Cited by PubMed: 23636324 DOI: 10.1038/nature12167 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation