4JKV

Structure of the human smoothened 7TM receptor in complex with an antitumor agent

4JKV の概要

• エントリーDOI: 10.2210/pdb4jkv/pdb
• 分子名称: Soluble cytochrome b562, Smoothened homolog, 4-fluoro-N-methyl-N-{1-[4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl]piperidin-4-yl}-2-(trifluoromethyl)benzamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (8 entities in total)
• 機能のキーワード: human smoothened receptor, antitumor agent, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, membrane
• 由来する生物種: Escherichia coli (human); 詳細
• 細胞内の位置: Membrane ; Multi-pass membrane protein : Q99835
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 110453.73

構造登録者

Wang, C.,Wu, H.,Katritch, V.,Han, G.W.,Huang, X.,Liu, W.,Siu, F.Y.,Roth, B.L.,Cherezov, V.,Stevens, R.C.,GPCR Network (GPCR) (登録日: 2013-03-11, 公開日: 2013-04-24, 最終更新日: 2024-04-03)

• 主引用文献: Wang, C.,Wu, H.,Katritch, V.,Han, G.W.,Huang, X.P.,Liu, W.,Siu, F.Y.,Roth, B.L.,Cherezov, V.,Stevens, R.C.; Structure of the human smoothened receptor bound to an antitumour agent.; Nature, 497:338-343, 2013; PubMed: 23636324; DOI: 10.1038/nature12167

実験手法

X-RAY DIFFRACTION (2.45 Å)