4JKV
Structure of the human smoothened 7TM receptor in complex with an antitumor agent
4JKV の概要
エントリーDOI | 10.2210/pdb4jkv/pdb |
分子名称 | Soluble cytochrome b562, Smoothened homolog, 4-fluoro-N-methyl-N-{1-[4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl]piperidin-4-yl}-2-(trifluoromethyl)benzamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (8 entities in total) |
機能のキーワード | human smoothened receptor, antitumor agent, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, membrane |
由来する生物種 | Escherichia coli (human) 詳細 |
細胞内の位置 | Membrane ; Multi-pass membrane protein : Q99835 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 110453.73 |
構造登録者 | Wang, C.,Wu, H.,Katritch, V.,Han, G.W.,Huang, X.,Liu, W.,Siu, F.Y.,Roth, B.L.,Cherezov, V.,Stevens, R.C.,GPCR Network (GPCR) (登録日: 2013-03-11, 公開日: 2013-04-24, 最終更新日: 2024-04-03) |
主引用文献 | Wang, C.,Wu, H.,Katritch, V.,Han, G.W.,Huang, X.P.,Liu, W.,Siu, F.Y.,Roth, B.L.,Cherezov, V.,Stevens, R.C. Structure of the human smoothened receptor bound to an antitumour agent. Nature, 497:338-343, 2013 Cited by PubMed: 23636324DOI: 10.1038/nature12167 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.45 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード