4JIY

RNA three-way junction stabilized by a supramolecular di-iron(II) cylinder drug

4JIY の概要

• エントリーDOI: 10.2210/pdb4jiy/pdb
• 関連するPDBエントリー: 2ET0 3FX8 3I1D
• 分子名称: 5'-(CGUACG)-3', N-[(1E)-PYRIDIN-2-YLMETHYLENE]-N-[4-(4-{[(1E)-PYRIDIN-2-YLMETHYLENE]AMINO}BENZYL)PHENYL]AMINE, FE (II) ION, ... (4 entities in total)
• 機能のキーワード: rna, three-way junction, drug-rna complex, rna structure recognition, cylinder, supramolecule
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 2867.48

構造登録者

Sigel, R.K.O.,Schnabl, J.A.,Freisinger, E.,Spingler, B.,Hannon, M.J. (登録日: 2013-03-07, 公開日: 2013-09-04, 最終更新日: 2024-02-28)

主引用文献

Phongtongpasuk, S.,Paulus, S.,Schnabl, J.,Sigel, R.K.,Spingler, B.,Hannon, M.J.,Freisinger, E.
Binding of a designed anti-cancer drug to the central cavity of an RNA three-way junction.
Angew.Chem.Int.Ed.Engl., 52:11513-11516, 2013

PubMed Abstract: Getting to the heart of it: Co-crystallization of an RNA three-way junction with a cylindrical di-iron(II)-based anti-cancer drug (green) results in π-stacking interactions between the cylinder and the central base pairs of the RNA structure. The shape, size, and cationic nature of the cylinder were found to be responsible for this perfect fit. Native gel electrophoresis studies confirmed stabilization of the RNA three-way junction by the iron(II) cylinder.

PubMed: 24039102
DOI: 10.1002/anie.201305079

実験手法

X-RAY DIFFRACTION (1.91 Å)