4JIK

X-RAY Crystal structure of compound 22a (R)-2-(4-chlorophenyl)-8-(piperidin-3-ylamino)imidazo[1,2-c]pyrimidine-5-carboxamide bound to human chk1 kinase domain

4JIK の概要

• エントリーDOI: 10.2210/pdb4jik/pdb
• 分子名称: Serine/threonine-protein kinase Chk1, 2-(4-chlorophenyl)-8-[(3S)-piperidin-3-ylamino]imidazo[1,2-c]pyrimidine-5-carboxamide (3 entities in total)
• 機能のキーワード: kinase phosphatase transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: O14757
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31826.07

構造登録者

Fischmann, T.O. (登録日: 2013-03-06, 公開日: 2013-04-17, 最終更新日: 2024-02-28)

• 主引用文献: Meng, Z.,Ciavarri, J.P.,McRiner, A.,Zhao, Y.,Zhao, L.,Reddy, P.A.,Zhang, X.,Fischmann, T.O.,Whitehurst, C.,Arshad Siddiqui, M.; Potency switch between CHK1 and MK2: discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors.; Bioorg.Med.Chem.Lett., 23:2863-2867, 2013; PubMed: 23587425; DOI: 10.1016/j.bmcl.2013.03.100

実験手法

X-RAY DIFFRACTION (1.9 Å)