4JG6

RSK2 CTD bound to 2-cyano-3-(1H-indazol-5-yl)acrylamide

Summary for 4JG6

Entry DOI	10.2210/pdb4jg6/pdb
Descriptor	Ribosomal protein S6 kinase alpha-3, (2S)-2-cyano-3-(1H-indazol-5-yl)propanamide, SODIUM ION, ... (4 entities in total)
Functional Keywords	protein kinase, phosphorylation, covalent inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus (By similarity): P51812
Total number of polymer chains	1
Total formula weight	40304.76
Authors	Miller, R.M.,Paavilainen, V.O.,Krishnan, S.,Serafimova, I.M.,Taunton, J. (deposition date: 2013-02-28, release date: 2013-04-10, Last modification date: 2013-04-24)
Primary citation	Miller, R.M.,Paavilainen, V.O.,Krishnan, S.,Serafimova, I.M.,Taunton, J. Electrophilic fragment-based design of reversible covalent kinase inhibitors. J.Am.Chem.Soc., 135:5298-5301, 2013 Cited by PubMed: 23540679 DOI: 10.1021/ja401221b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation