4JFL

Increasing the Efficiency Efficiency of Ligands for the FK506-Binding Protein 51 by Conformational Control: Complex of FKBP51 with 6-({(1S,5R)-3-[2-(3,4-dimethoxyphenoxy)ethyl]-2-oxo-3,9-diazabicyclo[3.3.1]non-9-yl}sulfonyl)-1,3-benzothiazol-2(3H)-one

4JFL の概要

• エントリーDOI: 10.2210/pdb4jfl/pdb
• 関連するPDBエントリー: 4JFI 4JFJ 4JFK 4JFM
• 分子名称: Peptidyl-prolyl cis-trans isomerase FKBP5, 6-({(1S,5R)-3-[2-(3,4-dimethoxyphenoxy)ethyl]-2-oxo-3,9-diazabicyclo[3.3.1]non-9-yl}sulfonyl)-1,3-benzothiazol-2(3H)-one (3 entities in total)
• 機能のキーワード: fk-506 binding domain, hsp90 cochaperone, immunophiline, peptidyl-prolyl isomerase, isomerase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q13451
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14559.69

構造登録者

Wang, Y.,Kirschner, A.,Fabian, A.,Gopalakrishnan, R.,Kress, C.,Hoogeland, B.,Koch, U.,Kozany, C.,Bracher, A.,Hausch, F. (登録日: 2013-02-28, 公開日: 2013-08-28, 最終更新日: 2024-02-28)

• 主引用文献: Wang, Y.,Kirschner, A.,Fabian, A.K.,Gopalakrishnan, R.,Kress, C.,Hoogeland, B.,Koch, U.,Kozany, C.,Bracher, A.,Hausch, F.; Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control.; J.Med.Chem., 56:3922-3935, 2013; PubMed: 23647266; DOI: 10.1021/jm400087k

実験手法

X-RAY DIFFRACTION (1.2 Å)