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4JDN

Secreted Chlamydial Protein PGP3, C-terminal Domain

4JDN の概要
エントリーDOI10.2210/pdb4jdn/pdb
関連するPDBエントリー4JDM 4JDO
分子名称Virulence plasmid protein pGP3-D, POTASSIUM ION, GLYCEROL, ... (4 entities in total)
機能のキーワードvirulence factor, secreted protein, chlamydia, inflammatory response, tnf, cell invasion
由来する生物種Chlamydia trachomatis
タンパク質・核酸の鎖数3
化学式量合計48028.58
構造登録者
Galaleldeen, A.,Taylor, A.B.,Chen, D.,Holloway, S.P.,Zhong, G.,Hart, P.J. (登録日: 2013-02-25, 公開日: 2013-06-05, 最終更新日: 2013-10-09)
主引用文献Galaleldeen, A.,Taylor, A.B.,Chen, D.,Schuermann, J.P.,Holloway, S.P.,Hou, S.,Gong, S.,Zhong, G.,Hart, P.J.
Structure of the Chlamydia trachomatis immunodominant antigen Pgp3.
J.Biol.Chem., 288:22068-22079, 2013
Cited by
PubMed Abstract: Chlamydia trachomatis infection is the most common sexually transmitted bacterial disease. Left untreated, it can lead to ectopic pregnancy, pelvic inflammatory disease, and infertility. Here we present the structure of the secreted C. trachomatis protein Pgp3, an immunodominant antigen and putative virulence factor. The ∼84-kDa Pgp3 homotrimer, encoded on a cryptic plasmid, consists of globular N- and C-terminal assemblies connected by a triple-helical coiled-coil. The C-terminal domains possess folds similar to members of the TNF family of cytokines. The closest Pgp3 C-terminal domain structural homologs include a lectin from Burkholderia cenocepacia, the C1q component of complement, and a portion of the Bacillus anthracis spore surface protein BclA, all of which play roles in bioadhesion. The N-terminal domain consists of a concatenation of structural motifs typically found in trimeric viral proteins. The central parallel triple-helical coiled-coil contains an unusual alternating pattern of apolar and polar residue pairs that generate a rare right-handed superhelical twist. The unique architecture of Pgp3 provides the basis for understanding its role in chlamydial pathogenesis and serves as the platform for its optimization as a potential vaccine antigen candidate.
PubMed: 23703617
DOI: 10.1074/jbc.M113.475012
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2 Å)
構造検証レポート
Validation report summary of 4jdn
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件を2024-10-30に公開中

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