4JBP

Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

Summary for 4JBP

Entry DOI	10.2210/pdb4jbp/pdb
Related	3K5U 3M11 4JBO 4JBQ
Descriptor	Aurora Kinase A, 1-(4-{2-[(6-{4-[2-(4-hydroxypiperidin-1-yl)ethoxy]phenyl}furo[2,3-d]pyrimidin-4-yl)amino]ethyl}phenyl)-3-phenylurea (3 entities in total)
Functional Keywords	aurora kinase inhibitors, hurp, mitotic spindle, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, centrosome: O14965
Total number of polymer chains	1
Total formula weight	32951.81
Authors	Wu, J.S.,Leou, J.S.,Peng, Y.H.,Hsueh, C.C.,Hsieh, H.P.,Wu, S.Y. (deposition date: 2013-02-20, release date: 2013-06-05, Last modification date: 2024-03-20)
Primary citation	Wu, J.M.,Chen, C.T.,Coumar, M.S.,Lin, W.H.,Chen, Z.J.,Hsu, J.T.,Peng, Y.H.,Shiao, H.Y.,Lin, W.H.,Chu, C.Y.,Wu, J.S.,Lin, C.T.,Chen, C.P.,Hsueh, C.C.,Chang, K.Y.,Kao, L.P.,Huang, C.Y.,Chao, Y.S.,Wu, S.Y.,Hsieh, H.P.,Chi, Y.H. Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules. Proc.Natl.Acad.Sci.USA, 110:E1779-E1787, 2013 Cited by PubMed: 23610398 DOI: 10.1073/pnas.1220523110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation