4JAN

crystal structure of broadly neutralizing antibody CH103 in complex with HIV-1 gp120

Summary for 4JAN

Related4J6R 4JAM 4JB9
DescriptorENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C, ANTIGEN BINDING FRAGMENT OF HEAVY CHAIN of CH103, ANTIGEN BINDING FRAGMENT OF LIGHT CHAIN of CH103, ... (7 entities in total)
Functional Keywordshiv-1, gp120, glycoprotein, viral protein-immune system complex, antibody, immunoglobulin, neutralization, vaccine, viral protein/immune system
Biological sourceHUMAN IMMUNODEFICIENCY VIRUS 1
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Total number of polymer chains6
Total molecular weight173850.4
Authors
Zhou, T.,Moquin, S.,Zheng, A.,Srivatsan, S.,Kwong, P.D. (deposition date: 2013-02-18, release date: 2013-04-03, Last modification date: 2019-01-09)
Primary citation
Liao, H.X.,Lynch, R.,Zhou, T.,Gao, F.,Alam, S.M.,Boyd, S.D.,Fire, A.Z.,Roskin, K.M.,Schramm, C.A.,Zhang, Z.,Zhu, J.,Shapiro, L.,Mullikin, J.C.,Gnanakaran, S.,Hraber, P.,Wiehe, K.,Kelsoe, G.,Yang, G.,Xia, S.M.,Montefiori, D.C.,Parks, R.,Lloyd, K.E.,Scearce, R.M.,Soderberg, K.A.,Cohen, M.,Kamanga, G.,Louder, M.K.,Tran, L.M.,Chen, Y.,Cai, F.,Chen, S.,Moquin, S.,Du, X.,Joyce, M.G.,Srivatsan, S.,Zhang, B.,Zheng, A.,Shaw, G.M.,Hahn, B.H.,Kepler, T.B.,Korber, B.T.,Kwong, P.D.,Mascola, J.R.,Haynes, B.F.
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.
Nature, 496:469-476, 2013
PubMed: 23552890 (PDB entries with the same primary citation)
DOI: 10.1038/nature12053
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.15 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2644 0.7% 1.8% 2.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution