4JA4

Inward open conformation of the xylose transporter XylE from E. coli

Summary for 4JA4

Entry DOI	10.2210/pdb4ja4/pdb
Related	4JA3
Descriptor	D-xylose-proton symporter, CADMIUM ION (2 entities in total)
Functional Keywords	mfs general substrate transporter, xylose transporter, transport protein
Biological source	Escherichia coli
Cellular location	Cell inner membrane; Multi-pass membrane protein: P0AGF4
Total number of polymer chains	3
Total formula weight	158889.79
Authors	Quistgaard, E.M.,Low, C.,Moberg, P.,Tresaugues, L.,Nordlund, P. (deposition date: 2013-02-18, release date: 2013-05-01, Last modification date: 2024-02-28)
Primary citation	Quistgaard, E.M.,Low, C.,Moberg, P.,Tresaugues, L.,Nordlund, P. Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters. Nat.Struct.Mol.Biol., 20:766-768, 2013 Cited by PubMed Abstract: Here we present two structures of the major facilitator (MFS) xylose transporter XylE from Escherichia coli in inward open and partially occluded inward open conformations. These structures provide key information about the transport cycle of XylE and the closely related human GLUT transporters. This is, to our knowledge, the first MFS transporter structure determined in more than one conformational state, which may establish XylE as an important MFS model protein. PubMed: 23624861 DOI: 10.1038/nsmb.2569 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4.2 Å)

Structure validation