4JA4

Inward open conformation of the xylose transporter XylE from E. coli

4JA4 の概要

• エントリーDOI: 10.2210/pdb4ja4/pdb
• 関連するPDBエントリー: 4JA3
• 分子名称: D-xylose-proton symporter, CADMIUM ION (2 entities in total)
• 機能のキーワード: mfs general substrate transporter, xylose transporter, transport protein
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cell inner membrane; Multi-pass membrane protein: P0AGF4
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 158889.79

構造登録者

Quistgaard, E.M.,Low, C.,Moberg, P.,Tresaugues, L.,Nordlund, P. (登録日: 2013-02-18, 公開日: 2013-05-01, 最終更新日: 2024-02-28)

主引用文献

Quistgaard, E.M.,Low, C.,Moberg, P.,Tresaugues, L.,Nordlund, P.
Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters.
Nat.Struct.Mol.Biol., 20:766-768, 2013

PubMed Abstract: Here we present two structures of the major facilitator (MFS) xylose transporter XylE from Escherichia coli in inward open and partially occluded inward open conformations. These structures provide key information about the transport cycle of XylE and the closely related human GLUT transporters. This is, to our knowledge, the first MFS transporter structure determined in more than one conformational state, which may establish XylE as an important MFS model protein.

PubMed: 23624861
DOI: 10.1038/nsmb.2569

実験手法

X-RAY DIFFRACTION (4.2 Å)