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4J4M

Crystal structure of TM-1, a Trimeresurus mucrosquamatus venom metalloproteinase

4J4M の概要
エントリーDOI10.2210/pdb4j4m/pdb
関連するPDBエントリー1KUF
分子名称zinc-dependent metalloproteinase, ZINC ION (3 entities in total)
機能のキーワードalpha/beta-mixed fold, endopeptidase, hydrolase
由来する生物種Protobothrops mucrosquamatus (Taiwan habu)
タンパク質・核酸の鎖数2
化学式量合計44011.74
構造登録者
Chou, T.L.,Wu, C.H.,Huang, K.F.,Wang, A.H. (登録日: 2013-02-07, 公開日: 2013-07-10, 最終更新日: 2023-11-08)
主引用文献Chou, T.L.,Wu, C.H.,Huang, K.F.,Wang, A.H.
Crystal structure of a Trimeresurus mucrosquamatus venom metalloproteinase providing new insights into the inhibition by endogenous tripeptide inhibitors.
Toxicon, 71C:140-146, 2013
Cited by
PubMed Abstract: The crystal structure of TM-1, a P-I class snake-venom metalloproteinase (SVMP) from the Trimeresurus mucrosquamatus venom, was determined at 1.8-Å resolution. The structure exhibits the typical feature of SVMPs and is stabilized by three disulfide linkages. The active site shows a deep S1' substrate-binding pocket limited by the non-conserved Pro174 at the bottom. Further comparisons with other SVMPs suggest that the deep S1' site of TM-1 correlates with its high inhibition sensitivity to the endogenous tripeptide inhibitors. Proteolytic specificity analysis revealed that TM-1 prefers substrates having a moderate-size and hydrophobic residue at the P1' position, consistent with our structural observation.
PubMed: 23732127
DOI: 10.1016/j.toxicon.2013.05.009
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.8 Å)
構造検証レポート
Validation report summary of 4j4m
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-10-30に公開中

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