4J1V

Functional and structural studies of MOBKL1B, a Salvador/Warts/Hippo tumor suppressor pathway, in HCV replication

4J1V の概要

• エントリーDOI: 10.2210/pdb4j1v/pdb
• 分子名称: MOB kinase activator 1A, NS5A domain II peptide, ZINC ION, ... (4 entities in total)
• 機能のキーワード: hcv ns5a binding protein, ns5a, peptide binding protein-viral protein complex, peptide binding protein/viral protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (Probable). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): Q99IB8
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 52516.55

構造登録者

Chung, H.-Y.,Gu, M.,Rice, C.M. (登録日: 2013-02-02, 公開日: 2014-08-06, 最終更新日: 2024-02-28)

• 主引用文献: Chung, H.Y.,Gu, M.,Buehler, E.,MacDonald, M.R.,Rice, C.M.; Seed Sequence-Matched Controls Reveal Limitations of Small Interfering RNA Knockdown in Functional and Structural Studies of Hepatitis C Virus NS5A-MOBKL1B Interaction.; J.Virol., 88:11022-11033, 2014; PubMed: 25031347; DOI: 10.1128/JVI.01582-14

実験手法

X-RAY DIFFRACTION (1.95 Å)