4J06
Crystal structure of hcv ns5b polymerase in complex with 2-{[(5-BROMOTHIOPHEN-2-YL)SULFONYL]AMINO}-4-CHLOROBENZOIC ACID
Summary for 4J06
Entry DOI | 10.2210/pdb4j06/pdb |
Related | 3MWV 4IZ0 4J02 4J04 4J08 4J0A |
Descriptor | Genome polyprotein, 2-{[(5-bromothiophen-2-yl)sulfonyl]amino}-4-chlorobenzoic acid (3 entities in total) |
Functional Keywords | rna-directed rna polymerase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Hepatitis C virus (HCV) |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): O92972 |
Total number of polymer chains | 2 |
Total formula weight | 129364.60 |
Authors | Coulombe, R. (deposition date: 2013-01-30, release date: 2013-04-17, Last modification date: 2023-09-20) |
Primary citation | Stammers, T.A.,Coulombe, R.,Rancourt, J.,Thavonekham, B.,Fazal, G.,Goulet, S.,Jakalian, A.,Wernic, D.,Tsantrizos, Y.,Poupart, M.A.,Bos, M.,McKercher, G.,Thauvette, L.,Kukolj, G.,Beaulieu, P.L. Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 23:2585-2589, 2013 Cited by PubMed: 23545108DOI: 10.1016/j.bmcl.2013.02.110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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