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4J04

Crystal structure of hcv ns5b polymerase in complex with 4-CHLORO-2-{[(2,4,5-TRICHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID

4J04 の概要
エントリーDOI10.2210/pdb4j04/pdb
関連するPDBエントリー3MWV 4IZ0 4J02 4J06 4J08 4J0A
分子名称Genome polyprotein, 4-chloro-2-{[(2,4,5-trichlorophenyl)sulfonyl]amino}benzoic acid, MANGANESE (II) ION, ... (4 entities in total)
機能のキーワードrna-directed rna polymerase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
由来する生物種Hepatitis C virus (HCV)
細胞内の位置Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): O92972
タンパク質・核酸の鎖数2
化学式量合計130036.25
構造登録者
Coulombe, R. (登録日: 2013-01-30, 公開日: 2013-04-17, 最終更新日: 2023-09-20)
主引用文献Stammers, T.A.,Coulombe, R.,Rancourt, J.,Thavonekham, B.,Fazal, G.,Goulet, S.,Jakalian, A.,Wernic, D.,Tsantrizos, Y.,Poupart, M.A.,Bos, M.,McKercher, G.,Thauvette, L.,Kukolj, G.,Beaulieu, P.L.
Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors.
Bioorg.Med.Chem.Lett., 23:2585-2589, 2013
Cited by
PubMed: 23545108
DOI: 10.1016/j.bmcl.2013.02.110
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2 Å)
構造検証レポート
Validation report summary of 4j04
検証レポート(詳細版)ダウンロードをダウンロード

217705

件を2024-03-27に公開中

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