4IWV

Crystals structure of Human Glucokinase in complex with small molecule activator

Summary for 4IWV

• Entry DOI: 10.2210/pdb4iwv/pdb
• Descriptor: Glucokinase isoform 3, SODIUM ION, alpha-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: allosteric site, catalysis, enzyme activation, gene expression regulation, glucokinase, glucose, homeostasis, humans, hypoglycemia, kinetics, biological, models, molecular, mutation, protein conformation, scattering, radiation, x-rays, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 51500.14

Authors

Ogg, D.J.,Hargreaves, D.,Gerhardt, S.,Flavell, L.,McAlister, M. (deposition date: 2013-01-24, release date: 2013-04-24, Last modification date: 2023-09-20)

• Primary citation: Waring, M.J.,Bennett, S.N.,Boyd, S.,Campbell, L.,Davies, R.D.M.,Ogg, D.J.,Hargreaves, D.,Martin, N.G.,Robb, G.,Wilkinson, S.,MacPaul, P.,Wood, J.M.; Optimising pharmacokinetics of glucokinase activators with matched triplicate design sets the discovery of AZD3651 and AZD9485; To be Published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)