4IVR

Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with IN52/10

4IVR の概要

• エントリーDOI: 10.2210/pdb4ivr/pdb
• 関連するPDBエントリー: 1E2P 3F0T 3RDP 4IVP 4IVQ
• 分子名称: Thymidine kinase, 2-[(2,6-dimethoxy-5-methylpyrimidin-4-yl)methylidene]propane-1,3-diol, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: dna synthesis, pet imaging tracer, atp binding, nucleotide binding, transferase
• 由来する生物種: Human herpesvirus 1 (HHV-1)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72230.81

構造登録者

Pernot, L.,Novakovic, I.,Westermaier, Y.,Perozzo, R.,Raic-Malic, S.,Scapozza, L. (登録日: 2013-01-23, 公開日: 2013-02-06, 最終更新日: 2023-09-20)

• 主引用文献: Pernot, L.,Novakovic, I.,Perozzo, R.,Raic-Malic, S.,Scapozza, L.; New thymine derivatives as HSV1-TK ligand for the development of PET imaging tracer; To be Published,

実験手法

X-RAY DIFFRACTION (2.4 Å)