Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4IU7

Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with Constrained WAY-derivative, 2b

Summary for 4IU7
Entry DOI10.2210/pdb4iu7/pdb
Related4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF
DescriptorEstrogen receptor, Nuclear receptor coactivator 2, 4-[2-ethyl-7-(trifluoromethyl)-2H-indazol-3-yl]benzene-1,3-diol, ... (4 entities in total)
Functional Keywordsnuclear hormone receptor, transcription factor, ligand binding, nucleus, transcription
Biological sourceHomo sapiens (human)
More
Cellular locationIsoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
Nucleus: Q15596
Total number of polymer chains4
Total formula weight59576.08
Authors
Nwachukwu, J.C.,Srinivasan, S.,Parent, A.A.,Cavett, V.,Nowak, J.,Hughes, T.S.,Kojetin, D.J.,Katzenellenbogen, J.A.,Nettles, K.W. (deposition date: 2013-01-20, release date: 2013-03-27, Last modification date: 2023-09-20)
Primary citationSrinivasan, S.,Nwachukwu, J.C.,Parent, A.A.,Cavett, V.,Nowak, J.,Hughes, T.S.,Kojetin, D.J.,Katzenellenbogen, J.A.,Nettles, K.W.
Ligand binding dynamics rewire cellular signaling via Estrogen Receptor-alpha
Nat.Chem.Biol., 9:326-332, 2013
Cited by
PubMed: 23524984
DOI: 10.1038/nchembio.1214
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.29 Å)
Structure validation

217705

数据于2024-03-27公开中

PDB statisticsPDBj update infoContact PDBjnumon