Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4IT7

Crystal structure of Al-CPI

4IT7 の概要
エントリーDOI10.2210/pdb4it7/pdb
分子名称CPI (2 entities in total)
機能のキーワードcpi, cystatin, hydrolase inhibitor
由来する生物種Ascaris lumbricoides (common roundworm)
タンパク質・核酸の鎖数4
化学式量合計48182.71
構造登録者
Mei, G.Q.,Liu, S.L.,Sun, M.Z.,Liu, J. (登録日: 2013-01-17, 公開日: 2014-01-29, 最終更新日: 2014-06-11)
主引用文献Mei, G.,Dong, J.,Li, Z.,Liu, S.,Liu, Y.,Sun, M.,Liu, G.,Su, Z.,Liu, J.
Structural Basis for the Immunomodulatory Function of Cysteine Protease Inhibitor from Human Roundworm Ascaris lumbricoides.
Plos One, 9:e96069-e96069, 2014
Cited by
PubMed Abstract: Immunosuppression associated with infections of nematode parasites has been documented. Cysteine protease inhibitor (CPI) released by the nematode parasites is identified as one of the major modulators of host immune response. In this report, we demonstrated that the recombinant CPI protein of Ascaris lumbricoides (Al-CPI) strongly inhibited the activities of cathepsin L, C, S, and showed weaker effect to cathepsin B. Crystal structure of Al-CPI was determined to 2.1 Å resolution. Two segments of Al-CPI, loop 1 and loop 2, were proposed as the key structure motifs responsible for Al-CPI binding with proteases and its inhibitory activity. Mutations at loop 1 and loop 2 abrogated the protease inhibition activity to various extents. These results provide the molecular insight into the interaction between the nematode parasite and its host and will facilitate the development of anthelmintic agents or design of anti-autoimmune disease drugs.
PubMed: 24781326
DOI: 10.1371/journal.pone.0096069
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.1 Å)
構造検証レポート
Validation report summary of 4it7
検証レポート(詳細版)ダウンロードをダウンロード

227111

件を2024-11-06に公開中

PDB statisticsPDBj update infoContact PDBjnumon