4ISV
Crystal structure of the Fab FRAGMENT OF 1C2, A MONOCLONAL ANTIBODY SPECIFIC FOR POLY-GLUTAMINE
Summary for 4ISV
Entry DOI | 10.2210/pdb4isv/pdb |
Related | 4IVU |
Descriptor | 1C2 FAB LIGHT CHAIN, 1C2 FAB HEAVY CHAIN (3 entities in total) |
Functional Keywords | 1c2, fab, vlx, neurodegeneration, polyglutamine disease, amyloid disease, immunoglobulin fold, immune system |
Biological source | Mus musculus More |
Total number of polymer chains | 2 |
Total formula weight | 47423.07 |
Authors | Klein, F.A.C.,Zeder-Lutz, G.,Cousido-Siah, A.,Mitschler, A.,Katz, A.,Eberling, P.,Mandel, J.L.,Podjarny, A.,Trottier, Y. (deposition date: 2013-01-17, release date: 2013-07-03, Last modification date: 2017-11-15) |
Primary citation | Klein, F.A.,Zeder-Lutz, G.,Cousido-Siah, A.,Mitschler, A.,Katz, A.,Eberling, P.,Mandel, J.L.,Podjarny, A.,Trottier, Y. Linear and extended: a common polyglutamine conformation recognized by the three antibodies MW1, 1C2 and 3B5H10. Hum.Mol.Genet., 22:4215-4223, 2013 Cited by PubMed: 23777629DOI: 10.1093/hmg/ddt273 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.497 Å) |
Structure validation
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