4ISV

Crystal structure of the Fab FRAGMENT OF 1C2, A MONOCLONAL ANTIBODY SPECIFIC FOR POLY-GLUTAMINE

Summary for 4ISV

• Entry DOI: 10.2210/pdb4isv/pdb
• Related: 4IVU
• Descriptor: 1C2 FAB LIGHT CHAIN, 1C2 FAB HEAVY CHAIN (3 entities in total)
• Functional Keywords: 1c2, fab, vlx, neurodegeneration, polyglutamine disease, amyloid disease, immunoglobulin fold, immune system
• Biological source: Mus musculus; More
• Total number of polymer chains: 2
• Total formula weight: 47423.07

Authors

Klein, F.A.C.,Zeder-Lutz, G.,Cousido-Siah, A.,Mitschler, A.,Katz, A.,Eberling, P.,Mandel, J.L.,Podjarny, A.,Trottier, Y. (deposition date: 2013-01-17, release date: 2013-07-03, Last modification date: 2017-11-15)

• Primary citation: Klein, F.A.,Zeder-Lutz, G.,Cousido-Siah, A.,Mitschler, A.,Katz, A.,Eberling, P.,Mandel, J.L.,Podjarny, A.,Trottier, Y.; Linear and extended: a common polyglutamine conformation recognized by the three antibodies MW1, 1C2 and 3B5H10.; Hum.Mol.Genet., 22:4215-4223, 2013; PubMed: 23777629; DOI: 10.1093/hmg/ddt273

Experimental method

X-RAY DIFFRACTION (1.497 Å)