4ILX
Structure of human carbonic anhydrase II in complex with an adamantyl sulfonamide inhibitor
Summary for 4ILX
| Entry DOI | 10.2210/pdb4ilx/pdb |
| Descriptor | Carbonic anhydrase 2, ZINC ION, GLYCEROL, ... (6 entities in total) |
| Functional Keywords | lyase, reversible hydration of carbon dioxide, cytosolic, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P00918 |
| Total number of polymer chains | 1 |
| Total formula weight | 29608.83 |
| Authors | Biswas, S.,McKenna, R. (deposition date: 2013-01-01, release date: 2013-02-13, Last modification date: 2024-02-28) |
| Primary citation | Biswas, S.,Carta, F.,Scozzafava, A.,McKenna, R.,Supuran, C.T. Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition. Bioorg.Med.Chem., 21:2314-2318, 2013 Cited by PubMed: 23490152DOI: 10.1016/j.bmc.2013.02.022 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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