4IKS

Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(6-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine

4IKS の概要

• エントリーDOI: 10.2210/pdb4iks/pdb
• 関連するPDBエントリー: 4IKR 4IKT 4IKU
• 分子名称: Methionine aminopeptidase 1, N-[5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl]-N'-[6-(trifluoromethyl)pyridin-2-yl]ethane-1,2-diamine, COBALT (II) ION, ... (6 entities in total)
• 機能のキーワード: pita-bread fold, aminopeptidase, ribosome, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37652.72

構造登録者

Addlagatta, A.,Kishor, C.,Arya, T. (登録日: 2012-12-28, 公開日: 2013-12-11, 最終更新日: 2024-03-20)

• 主引用文献: Kishor, C.,Arya, T.,Reddi, R.,Chen, X.,Saddanapu, V.,Marapaka, A.K.,Gumpena, R.,Ma, D.,Liu, J.O.,Addlagatta, A.; Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases; J.Med.Chem., 56:5295-5305, 2013; PubMed: 23767698; DOI: 10.1021/jm400395p

実験手法

X-RAY DIFFRACTION (1.7 Å)