4IKR

Crystal structure of Type 1 human methionine aminopeptidase in complex with 2-(4-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)piperazin-1-yl)ethanol

Summary for 4IKR

Entry DOI	10.2210/pdb4ikr/pdb
Related	2NQ7 4IKS 4IKT 4IKU
Descriptor	Methionine aminopeptidase 1, COBALT (II) ION, 2-{4-[5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl]piperazin-1-yl}ethanol, ... (6 entities in total)
Functional Keywords	pita-bread fold, aminopeptidase, ribosome, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	37577.73
Authors	Addlagatta, A.,Kishor, C.,Arya, T. (deposition date: 2012-12-28, release date: 2013-12-11, Last modification date: 2024-03-20)
Primary citation	Kishor, C.,Arya, T.,Reddi, R.,Chen, X.,Saddanapu, V.,Marapaka, A.K.,Gumpena, R.,Ma, D.,Liu, J.O.,Addlagatta, A. Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases J.Med.Chem., 56:5295-5305, 2013 Cited by PubMed: 23767698 DOI: 10.1021/jm400395p PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation