4IKR

Crystal structure of Type 1 human methionine aminopeptidase in complex with 2-(4-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)piperazin-1-yl)ethanol

4IKR の概要

• エントリーDOI: 10.2210/pdb4ikr/pdb
• 関連するPDBエントリー: 2NQ7 4IKS 4IKT 4IKU
• 分子名称: Methionine aminopeptidase 1, COBALT (II) ION, 2-{4-[5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl]piperazin-1-yl}ethanol, ... (6 entities in total)
• 機能のキーワード: pita-bread fold, aminopeptidase, ribosome, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37577.73

構造登録者

Addlagatta, A.,Kishor, C.,Arya, T. (登録日: 2012-12-28, 公開日: 2013-12-11, 最終更新日: 2024-03-20)

• 主引用文献: Kishor, C.,Arya, T.,Reddi, R.,Chen, X.,Saddanapu, V.,Marapaka, A.K.,Gumpena, R.,Ma, D.,Liu, J.O.,Addlagatta, A.; Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases; J.Med.Chem., 56:5295-5305, 2013; PubMed: 23767698; DOI: 10.1021/jm400395p

実験手法

X-RAY DIFFRACTION (1.78 Å)