4IJ1
Bianthranilate-like analogue bound to anthranilate phosphoribosyltransferase (AnPRT; trpD) in absence of substrates.
Summary for 4IJ1
Entry DOI | 10.2210/pdb4ij1/pdb |
Related | 4GIU 4GKM |
Descriptor | Anthranilate phosphoribosyltransferase, 2,2'-iminodibenzoic acid, GLYCEROL, ... (5 entities in total) |
Functional Keywords | inhibitor complex, bi-anthranilate analogue, tb structural genomics consortium, tbsgc, phosphoribosyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 79193.34 |
Authors | Evans, G.L.,Baker, E.N.,Lott, J.S.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2012-12-20, release date: 2013-12-25, Last modification date: 2023-09-20) |
Primary citation | Evans, G.L.,Gamage, S.A.,Bulloch, E.M.,Baker, E.N.,Denny, W.A.,Lott, J.S. Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis. Chembiochem, 15:852-864, 2014 Cited by PubMed: 24623674DOI: 10.1002/cbic.201300628 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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