4IJ1

Bianthranilate-like analogue bound to anthranilate phosphoribosyltransferase (AnPRT; trpD) in absence of substrates.

4IJ1 の概要

• エントリーDOI: 10.2210/pdb4ij1/pdb
• 関連するPDBエントリー: 4GIU 4GKM
• 分子名称: Anthranilate phosphoribosyltransferase, 2,2'-iminodibenzoic acid, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: inhibitor complex, bi-anthranilate analogue, tb structural genomics consortium, tbsgc, phosphoribosyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 79193.34

構造登録者

Evans, G.L.,Baker, E.N.,Lott, J.S.,TB Structural Genomics Consortium (TBSGC) (登録日: 2012-12-20, 公開日: 2013-12-25, 最終更新日: 2023-09-20)

• 主引用文献: Evans, G.L.,Gamage, S.A.,Bulloch, E.M.,Baker, E.N.,Denny, W.A.,Lott, J.S.; Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.; Chembiochem, 15:852-864, 2014; PubMed: 24623674; DOI: 10.1002/cbic.201300628

実験手法

X-RAY DIFFRACTION (1.79 Å)