4IE1

Crystal structure of human Arginase-1 complexed with inhibitor 1h

Summary for 4IE1

• Entry DOI: 10.2210/pdb4ie1/pdb
• Related: 1D3V 2AEB
• Descriptor: Arginase-1, [(5R)-5-amino-5-carboxy-8-hydroxyoctyl](trihydroxy)borate(1-), MANGANESE (II) ION, ... (4 entities in total)
• Functional Keywords: boron compounds, metalloenzyme, alpha/beta fold, hydrolase, arginine metabolism, manganese, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P05089
• Total number of polymer chains: 2
• Total formula weight: 68567.59

Authors

Cousido-Siah, A.,Mitschler, A.,Ruiz, F.X.,Beckett, P.,Van Zandt, M.C.,Ji, M.K.,Whitehouse, D.,Ryder, T.,Jagdmann, E.,Andreoli, M.,Mazur, A.,Padmanilayam, M.,Schroeter, H.,Golebiowski, A.,Podjarny, A. (deposition date: 2012-12-13, release date: 2013-03-20, Last modification date: 2023-09-20)

• Primary citation: Golebiowski, A.,Paul Beckett, R.,Van Zandt, M.,Ji, M.K.,Whitehouse, D.,Ryder, T.R.,Jagdmann, E.,Andreoli, M.,Mazur, A.,Padmanilayam, M.,Cousido-Siah, A.,Mitschler, A.,Ruiz, F.X.,Podjarny, A.,Schroeter, H.; 2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors.; Bioorg.Med.Chem.Lett., 23:2027-2030, 2013; PubMed: 23453840; DOI: 10.1016/j.bmcl.2013.02.024

Experimental method

X-RAY DIFFRACTION (2.0006 Å)