4ICA

Crystal structure of a C-terminal truncated form of the matrix subunit (p15) of Feline Immunodeficiency Virus (FIV)

Summary for 4ICA

• Entry DOI: 10.2210/pdb4ica/pdb
• Related: 4IC9
• Descriptor: Matrix protein p15, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL (3 entities in total)
• Functional Keywords: fiv, p15, retroviral matrix protein, viral protein
• Biological source: Feline immunodeficiency virus (FIV)
• Cellular location: Matrix protein p15: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p13: Virion (Potential): P16087
• Total number of polymer chains: 2
• Total formula weight: 30186.73

Authors

Serriere, J.,Robert, X.,Perez, M.,Gouet, P.,Guillon, C. (deposition date: 2012-12-10, release date: 2013-07-10, Last modification date: 2024-04-03)

Primary citation

Serriere, J.,Robert, X.,Perez, M.,Gouet, P.,Guillon, C.
Biophysical characterization and crystal structure of the Feline Immunodeficiency Virus p15 matrix protein.
Retrovirology, 10:64-64, 2013

PubMed Abstract: Feline Immunodeficiency Virus (FIV) is a viral pathogen that infects domestic cats and wild felids. During the viral replication cycle, the FIV p15 matrix protein oligomerizes to form a closed matrix that underlies the lipidic envelope of the virion. Because of its crucial role in the early and late stages of viral morphogenesis, especially in viral assembly, FIV p15 is an interesting target in the development of potential new therapeutic strategies.

PubMed: 23800358
DOI: 10.1186/1742-4690-10-64

Experimental method

X-RAY DIFFRACTION (2.7 Å)